What the FDA labels say about taking them together
Diazepam and fluoxetine
Diazepam's FDA label of August 11, 2026 names fluoxetine in its drug interactions section, and fluoxetine's label names diazepam too. The fluoxetine label: “Diazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels Antipsychotics:”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the diazepam label say about fluoxetine?
Diazepam label, drug interactionsAt present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the fluoxetine label say about diazepam?
Fluoxetine label, drug interactionsDiazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels ( 7.7 ) Antipsychotics:
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Fluoxetine | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | Depression, Anxiety, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once