What the FDA labels say about taking them together
Alprazolam and fluoxetine
Fluoxetine's FDA label of January 8, 2026 names alprazolam in its drug interactions section; the alprazolam labels PlainMeds reads (2) do not name fluoxetine. The fluoxetine label: “Diazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels Antipsychotics:”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the alprazolam label say about fluoxetine?
Alprazolam's label (effective January 18, 2023) and its 1 other brand-application label do not name fluoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the fluoxetine label say about alprazolam?
Fluoxetine label, drug interactionsDiazepam – increased t½, alprazolam - further psychomotor performance decrement due to increased levels ( 7.7 ) Antipsychotics:
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Fluoxetine | |
|---|---|---|
| Labeled for | Anxiety | Depression, Anxiety, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once