What the FDA labels say about taking them together
Flunisolide and prednisone
Flunisolide's FDA label of January 16, 2025 names prednisone in its warnings section; prednisone's label does not name flunisolide itself but warns about its class (Corticosteroids). The flunisolide label: “The use of flunisolide with alternate-day prednisone systemic treatment could increase the likelihood of HPA suppression compared to a therapeutic dose of either one alone.”
Check it at the source: the flunisolide FDA label on DailyMed (effective January 16, 2025, Bausch & Lomb Incorporated); the prednisone FDA label on DailyMed (effective April 22, 2025, Hikma Pharmaceuticals USA Inc.).
What does the flunisolide label say about prednisone?
Flunisolide label, warningsThe use of flunisolide with alternate-day prednisone systemic treatment could increase the likelihood of HPA suppression compared to a therapeutic dose of either one alone.
Source: FDA drug label (Flunisolide), Bausch & Lomb Incorporated, effective January 16, 2025 (SPL set 7c72c954-3758-40c3-9977-d03b25d71e0a), via openFDA; the full label on DailyMed
What does the prednisone label say about flunisolide?
Prednisone's label does not name flunisolide itself; it warns about its class (Corticosteroids):
Prednisone label, warningsVaricella Zoster and Measles Viral Infections Varicella and measles can have a serious or even fatal course in non-immune patients taking corticosteroids, including prednisone.
Prednisone label, warningsWARNINGS In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.
Source: FDA drug label (PredniSONE), Hikma Pharmaceuticals USA Inc., effective April 22, 2025 (SPL set 3115aef0-fd50-4ec8-a064-3effb695f3f2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flunisolide | Prednisone | |
|---|---|---|
| Labeled for | n/a | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Eczema (atopic dermatitis), Anemia, Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.99 per mL 0.025% spray | $0.0643 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once