What the FDA labels say about taking them together
Flumazenil and oxazepam
Oxazepam's FDA label of July 11, 2025 names flumazenil in its warnings section; flumazenil's label does not name oxazepam itself but warns about its class (Benzodiazepines). The oxazepam label: “Abrupt discontinuation or rapid dosage reduction of oxazepam after continued use, or administration of flumazenil may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) [see DRUG …”
Check it at the source: the flumazenil FDA label on DailyMed (effective June 21, 2024, Hikma Pharmaceuticals USA Inc.); the oxazepam FDA label on DailyMed (effective July 11, 2025, Leading Pharma, LLC).
What does the flumazenil label say about oxazepam?
Flumazenil's label does not name oxazepam itself; it warns about its class (Benzodiazepines):
Flumazenil label, contraindicationsCONTRAINDICATIONS Flumazenil is contraindicated: in patients with a known hypersensitivity to flumazenil or benzodiazepines. in patients who have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., control of intracranial pressure or status epilepticus). in patients who are showing signs of serious cyclic antidepressant overdose (see WARNINGS ).
Flumazenil label, boxed warningTHESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE.
Source: FDA drug label (Flumazenil), Hikma Pharmaceuticals USA Inc., effective June 21, 2024 (SPL set 436f5616-9626-4b6a-9deb-2986444179d0), via openFDA; the full label on DailyMed
What does the oxazepam label say about flumazenil?
Oxazepam label, warningsAbrupt discontinuation or rapid dosage reduction of oxazepam after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) [see DRUG ABUSE AND DEPENDENCE:
Source: FDA drug label (OXAZEPAM), Leading Pharma, LLC, effective July 11, 2025 (SPL set 67f821fa-5663-4d69-82c9-5ee13a09f324), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flumazenil | Oxazepam | |
|---|---|---|
| Labeled for | n/a | Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.18 per mL 0.5 mg/5 mL vial | $0.725 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once