What the FDA labels say about taking them together
Flumazenil and lorazepam
Lorazepam's FDA label of July 9, 2025 names flumazenil in its warnings section; flumazenil's label does not name lorazepam itself but warns about its class (Benzodiazepines). The lorazepam label: “Abrupt discontinuation or rapid dosage reduction of LOREEV XR after continued use, or administration of flumazenil may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures).”
Check it at the source: the flumazenil FDA label on DailyMed (effective June 21, 2024, Hikma Pharmaceuticals USA Inc.); the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC).
What does the flumazenil label say about lorazepam?
Flumazenil's label does not name lorazepam itself; it warns about its class (Benzodiazepines):
Flumazenil label, contraindicationsCONTRAINDICATIONS Flumazenil is contraindicated: in patients with a known hypersensitivity to flumazenil or benzodiazepines. in patients who have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., control of intracranial pressure or status epilepticus). in patients who are showing signs of serious cyclic antidepressant overdose (see WARNINGS ).
Flumazenil label, boxed warningTHESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE.
Source: FDA drug label (Flumazenil), Hikma Pharmaceuticals USA Inc., effective June 21, 2024 (SPL set 436f5616-9626-4b6a-9deb-2986444179d0), via openFDA; the full label on DailyMed
What does the lorazepam label say about flumazenil?
Lorazepam label, warningsAbrupt discontinuation or rapid dosage reduction of Ativan after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) (see DRUG ABUSE AND DEPENDENCE:
Source: FDA drug label (Loreev Xr, NDA214826), Almatica Pharma LLC, effective October 8, 2025 (SPL set 227734c1-bf01-9607-73ea-5a1f38a89bd9), via openFDA
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Flumazenil | Lorazepam | |
|---|---|---|
| Labeled for | n/a | Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.18 per mL 0.5 mg/5 mL vial | $0.0344 per tablet 0.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once