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What the FDA labels say about taking them together

Flucytosine and ganciclovir

Ganciclovir's FDA label of January 9, 2026 names flucytosine in its drug interactions section; the flucytosine label PlainMeds reads does not name ganciclovir. The ganciclovir label: “Because of potential for higher toxicity, coadministration with Ganciclovir should be considered only if the potential benefits are judged to outweigh the risks.”

Check it at the source: the flucytosine FDA label on DailyMed (effective February 2, 2022, Bausch Health US LLC); the ganciclovir FDA label on DailyMed (effective January 9, 2026, Fresenius Kabi USA, LLC).

What does the flucytosine label say about ganciclovir?

Flucytosine's label (effective February 2, 2022) does not name ganciclovir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (ANCOBON), Bausch Health US LLC, effective February 2, 2022 (SPL set aea0df00-a88c-4a16-abcf-750f3ff2004e), via openFDA; the full label on DailyMed

What does the ganciclovir label say about flucytosine?

Ganciclovir label, drug interactions

Name of the Concomitant Drug: Other drugs associated with myelosuppression or nephrotoxicity (e.g., dapsone, doxorubicin, flucytosine, hydroxyurea, pentamidine, tacrolimus, trimethoprim/sulfamethoxazole, vinblastine, vincristine and zidovudine); Change in the Concentration of Ganciclovir or Concomitant Drug: Unknown; Clinical Comment: Because of potential for higher toxicity, coadministration with Ganciclovir should be considered only if the potential benefits are judged to outweigh the risks.

Source: FDA drug label (Ganciclovir), Fresenius Kabi USA, LLC, effective January 9, 2026 (SPL set 35addab5-09db-4f8a-9c69-6fbce33ecc37), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

9Flucytosine generic labelers
6Ganciclovir generic labelers
FlucytosineGanciclovir
Labeled forFungal infectionsn/a
Boxed warningYesYes
Pharmacy cost (NADAC)n/a$91.24 per gram 0.15% ophthalmic gel
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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