What the FDA labels say about taking them together
Fluconazole and zidovudine
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names zidovudine in its drug interactions section, and zidovudine's label names fluconazole too. The fluconazole label: “Drug Interaction Studies. ) Zidovudine Fluconazole increases the C max and AUC of zidovudine by 84% and 74%, respectively, due to an approximately 45% decrease in oral zidovudine clearance.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the fluconazole label say about zidovudine?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsDrug Interaction Studies. ) Zidovudine Fluconazole increases the C max and AUC of zidovudine by 84% and 74%, respectively, due to an approximately 45% decrease in oral zidovudine clearance.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the zidovudine label say about fluconazole?
Retrovir label (ViiV Healthcare Company, October 30, 2013), drug interactionsFor patients experiencing pronounced anemia or other severe zidovudine-associated events while receiving chronic administration of zidovudine and some of the drugs (e.g., fluconazole, valproic acid) listed in Table 4, zidovudine dose reduction may be considered.
Source: FDA drug label (Retrovir, NDA019951), ViiV Healthcare Company, effective October 30, 2013 (SPL set 360d8a6d-d3b6-43ef-8764-e99d831880a4), via openFDA
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Zidovudine | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.464 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once