What the FDA labels say about taking them together
Fluconazole and zafirlukast
Zafirlukast's FDA label of December 1, 2023 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name zafirlukast. The zafirlukast label: “Coadministration of zafirlukast with fluconazole, a moderate CYP2C9 inhibitor, resulted in increased plasma levels of zafirlukast, by approximately 58% (90% CI:28, 95).”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the zafirlukast FDA label on DailyMed (effective December 1, 2023, Aurobindo Pharma Limited).
What does the fluconazole label say about zafirlukast?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name zafirlukast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the zafirlukast label say about fluconazole?
Zafirlukast label, drug interactionsCoadministration of zafirlukast with fluconazole, a moderate CYP2C9 inhibitor, resulted in increased plasma levels of zafirlukast, by approximately 58% (90% CI:28, 95).
Source: FDA drug label (Zafirlukast), Aurobindo Pharma Limited, effective December 1, 2023 (SPL set 8bdb47c5-9d19-4d59-94c8-62c117525e7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Zafirlukast | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.623 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once