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What the FDA labels say about taking them together

Fluconazole and vitamin a

Fluconazole's FDA label (Fluconazole) of April 2, 2026 names vitamin a in its drug interactions section; the vitamin a label PlainMeds reads does not name fluconazole.

Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the vitamin a FDA label on DailyMed (effective March 3, 2026, Rising Pharma Holdings, Inc.).

What does the fluconazole label say about vitamin a?

Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactions

Vitamin A Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of fluconazole treatment.

Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA

Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed

What does the vitamin a label say about fluconazole?

Vitamin a's label (effective March 3, 2026) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (AQUASOL A Parenteral), Rising Pharma Holdings, Inc., effective March 3, 2026 (SPL set 1abd66eb-6ac8-4a9e-a609-251e46ea1a27), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

41Fluconazole generic labelers
0Vitamin a generic labelers
FluconazoleVitamin a
Labeled forFungal infections, Urinary tract infectionsn/a
Boxed warningNoNo
Pharmacy cost (NADAC)$0.380 per tablet 200 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?