What the FDA labels say about taking them together
Fluconazole and vinblastine
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names vinblastine in its drug interactions section; the vinblastine label PlainMeds reads does not name fluconazole. The fluconazole label: “Vinca alkaloids Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids and lead to neurotoxicity, which is possibly due to an inhibitory effect on CYP3A4.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the vinblastine FDA label on DailyMed (effective April 15, 2025, Fresenius Kabi USA, LLC).
What does the fluconazole label say about vinblastine?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsVinca alkaloids Although not studied, fluconazole may increase the plasma levels of the vinca alkaloids (e.g., vincristine and vinblastine) and lead to neurotoxicity, which is possibly due to an inhibitory effect on CYP3A4.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the vinblastine label say about fluconazole?
Vinblastine's label (effective April 15, 2025) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vinblastine Sulfate), Fresenius Kabi USA, LLC, effective April 15, 2025 (SPL set f073b58e-56d6-4c8d-a2ce-b37719402d77), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Vinblastine | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once