What the FDA labels say about taking them together
Fluconazole and ubrogepant
Ubrogepant's FDA label of June 5, 2025 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name ubrogepant. The ubrogepant label: “Dose adjustment is recommended with concomitant use of UBRELVY and moderate CYP3A4 inhibitors.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the ubrogepant FDA label on DailyMed (effective June 5, 2025, Allergan, Inc.).
What does the fluconazole label say about ubrogepant?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name ubrogepant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the ubrogepant label say about fluconazole?
Ubrogepant label, drug interactionsDose adjustment is recommended with concomitant use of UBRELVY and moderate CYP3A4 inhibitors (e.g., cyclosporine, ciprofloxacin, fluconazole, fluvoxamine, grapefruit juice) [see Dosage and Administration ( 2.2 )].
Source: FDA drug label (UBRELVY), NDA211765 (Abbvie), as published by Allergan, Inc., effective June 5, 2025 (SPL set fd9f9458-fd96-4688-be3f-f77b3d1af6ab), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Ubrogepant | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $109.11 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once