What the FDA labels say about taking them together
Fluconazole and tolvaptan
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names tolvaptan in its drug interactions section; the tolvaptan labels PlainMeds reads (2) do not name fluconazole. The fluconazole label: “Drug Interaction Studies. ) Tolvaptan Plasma exposure to tolvaptan is significantly increased (200% in AUC;”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the tolvaptan FDA label on DailyMed (effective May 7, 2026, Otsuka America Pharmaceutical, Inc.).
What does the fluconazole label say about tolvaptan?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsDrug Interaction Studies. ) Tolvaptan Plasma exposure to tolvaptan is significantly increased (200% in AUC;
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the tolvaptan label say about fluconazole?
Tolvaptan's label (effective May 7, 2026) and its 1 other brand-application label do not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SAMSCA), Otsuka America Pharmaceutical, Inc., effective May 7, 2026 (SPL set 5526617c-c7b9-4556-886d-729bbabbc566), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Tolvaptan | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $14.57 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once