What the FDA labels say about taking them together
Fluconazole and selumetinib
Selumetinib's FDA label of May 26, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name selumetinib. The selumetinib label: “Strong or Moderate CYP3A4 Inhibitors or Fluconazole: Avoid coadministration of strong or moderate CYP3A4 inhibitors or fluconazole with KOSELUGO.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the selumetinib FDA label on DailyMed (effective May 26, 2026, AstraZeneca Pharmaceuticals LP).
What does the fluconazole label say about selumetinib?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name selumetinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the selumetinib label say about fluconazole?
Selumetinib label, drug interactionsStrong or Moderate CYP3A4 Inhibitors or Fluconazole: Avoid coadministration of strong or moderate CYP3A4 inhibitors or fluconazole with KOSELUGO.
Source: FDA drug label (KOSELUGO), AstraZeneca Pharmaceuticals LP, effective May 26, 2026 (SPL set 7d042c61-f28f-4ab5-ab10-d7558c0d49ff), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Selumetinib | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once