What the FDA labels say about taking them together
Fluconazole and rifampin
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name fluconazole.
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the fluconazole label say about rifampin?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsDrug Interaction Studies .) Rifampin Rifampin enhances the metabolism of concurrently administered fluconazole.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the rifampin label say about fluconazole?
Rifampin's label (effective February 11, 2026) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Rifampin | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once