What the FDA labels say about taking them together
Fluconazole and ospemifene
Ospemifene's FDA label of February 14, 2025 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name ospemifene. The ospemifene label: “Fluconazole increases serum concentrations of OSPHENA. Do not use rifampin concomitantly with OSPHENA.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the ospemifene FDA label on DailyMed (effective February 14, 2025, Duchesnay USA, Inc.).
What does the fluconazole label say about ospemifene?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name ospemifene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the ospemifene label say about fluconazole?
Ospemifene label, drug interactionsFluconazole increases serum concentrations of OSPHENA. ( 7.2 , 12.3 ) Do not use rifampin concomitantly with OSPHENA.
Source: FDA drug label (Osphena), Duchesnay USA, Inc., effective February 14, 2025 (SPL set 9accbcc9-78ee-4f84-9b7e-704f2ab1c413), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Ospemifene | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $8.17 per tablet 60 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once