What the FDA labels say about taking them together
Fluconazole and olaparib
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names olaparib in its drug interactions section; the olaparib label PlainMeds reads does not name fluconazole. The fluconazole label: “Olaparib Moderate inhibitors of CYP3A4 such as fluconazole increase olaparib plasma concentrations; concomitant use is not recommended.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the olaparib FDA label on DailyMed (effective July 10, 2025, AstraZeneca Pharmaceuticals LP).
What does the fluconazole label say about olaparib?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsOlaparib Moderate inhibitors of CYP3A4 such as fluconazole increase olaparib plasma concentrations; concomitant use is not recommended.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the olaparib label say about fluconazole?
Olaparib's label (effective July 10, 2025) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lynparza), AstraZeneca Pharmaceuticals LP, effective July 10, 2025 (SPL set 741ff3e3-dc1a-45a6-84e5-2481b27131aa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Olaparib | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Breast cancer, Prostate cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once