What the FDA labels say about taking them together
Fluconazole and nortriptyline
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names nortriptyline in its drug interactions section; the nortriptyline label PlainMeds reads does not name fluconazole. The fluconazole label: “Amitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the nortriptyline FDA label on DailyMed (effective December 4, 2024).
What does the fluconazole label say about nortriptyline?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsAmitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the nortriptyline label say about fluconazole?
Nortriptyline's label (effective December 4, 2024) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Nortriptyline | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.113 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once