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What the FDA labels say about taking them together

Fluconazole and nevirapine

Nevirapine's FDA label of July 15, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name nevirapine. The nevirapine label: “Because of the risk of increased exposure to nevirapine, caution should be used in concomitant administration, and patients should be monitored closely for nevirapine-associated adverse events.”

Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).

What does the fluconazole label say about nevirapine?

Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name nevirapine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed

What does the nevirapine label say about fluconazole?

Nevirapine label, drug interactions

Drug Name: Antifungals: Fluconazole; Effect on Concentration of Nevirapine or Concomitant Drug: ↑ Nevirapine; Clinical Comment: Because of the risk of increased exposure to nevirapine, caution should be used in concomitant administration, and patients should be monitored closely for nevirapine-associated adverse events.

Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

41Fluconazole generic labelers
6Nevirapine generic labelers
FluconazoleNevirapine
Labeled forFungal infections, Urinary tract infectionsHIV
Boxed warningNoYes
Pharmacy cost (NADAC)$0.380 per tablet 200 mg tablet$0.147 per tablet 200 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?