What the FDA labels say about taking them together
Fluconazole and lorlatinib
Lorlatinib's FDA label of June 26, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name lorlatinib. The lorlatinib label: “Fluconazole Avoid concomitant use of LORBRENA with fluconazole.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the lorlatinib FDA label on DailyMed (effective June 26, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the fluconazole label say about lorlatinib?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name lorlatinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the lorlatinib label say about fluconazole?
Lorlatinib label, drug interactionsFluconazole Avoid concomitant use of LORBRENA with fluconazole.
Source: FDA drug label (Lorbrena), Pfizer Laboratories Div Pfizer Inc, effective June 26, 2026 (SPL set 2b34d62d-e02a-4af3-bc0d-1571dd4ee76d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Lorlatinib | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Lung cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once