What the FDA labels say about taking them together
Fluconazole and ibrutinib
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names ibrutinib in its drug interactions section; the ibrutinib label PlainMeds reads does not name fluconazole. The fluconazole label: “Ibrutinib Moderate inhibitors of CYP3A4 such as fluconazole may increase plasma ibrutinib concentrations and increase risk of adverse reactions associated with ibrutinib.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the ibrutinib FDA label on DailyMed (effective October 21, 2025).
What does the fluconazole label say about ibrutinib?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsIbrutinib Moderate inhibitors of CYP3A4 such as fluconazole may increase plasma ibrutinib concentrations and increase risk of adverse reactions associated with ibrutinib.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the ibrutinib label say about fluconazole?
Ibrutinib's label (effective October 21, 2025) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imbruvica), Pharmacyclics LLC, effective October 21, 2025 (SPL set 0dfd0279-ff17-4ea9-89be-9803c71bab44), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Ibrutinib | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Leukemia, lymphoma and myeloma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once