What the FDA labels say about taking them together
Fluconazole and glyburide
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names glyburide in its drug interactions section; the glyburide label PlainMeds reads does not name fluconazole. The fluconazole label: “… been reported from hypoglycemia in association with combined fluconazole and glyburide use.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc).
What does the fluconazole label say about glyburide?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsOral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined fluconazole and glyburide use.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the glyburide label say about fluconazole?
Glyburide's label (effective July 1, 2021) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Glyburide | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.0643 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once