What the FDA labels say about taking them together
Fluconazole and flurbiprofen
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names flurbiprofen in its drug interactions section; the flurbiprofen label PlainMeds reads does not name fluconazole. The fluconazole label: “Non-steroidal anti-inflammatory drugs The C max and AUC of flurbiprofen were increased by 23% and 81%, respectively, when coadministered with fluconazole compared to administration of flurbiprofen alone.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the flurbiprofen FDA label on DailyMed (effective July 24, 2024, Bausch & Lomb Incorporated).
What does the fluconazole label say about flurbiprofen?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsNon-steroidal anti-inflammatory drugs The C max and AUC of flurbiprofen were increased by 23% and 81%, respectively, when coadministered with fluconazole compared to administration of flurbiprofen alone.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the flurbiprofen label say about fluconazole?
Flurbiprofen's label (effective July 24, 2024) does not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Flurbiprofen Sodium), Bausch & Lomb Incorporated, effective July 24, 2024 (SPL set 11db354f-caf9-4567-811e-6c9beb1330c7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Flurbiprofen | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $9.83 per mL 0.03% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once