What the FDA labels say about taking them together
Diclofenac and fluconazole
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names diclofenac in its drug interactions section; the diclofenac labels PlainMeds reads (4) do not name fluconazole. The fluconazole label: “Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9.”
Check it at the source: the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the diclofenac label say about fluconazole?
Diclofenac's label (effective February 11, 2025) and its 3 other brand-application labels do not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
What does the fluconazole label say about diclofenac?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsAlthough not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diclofenac | Fluconazole | |
|---|---|---|
| Labeled for | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0619 per tablet 75 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once