What the FDA labels say about taking them together
Cyclosporine and fluconazole
Cyclosporine's FDA label of August 10, 2026 names fluconazole in its drug interactions section, and fluconazole's label names cyclosporine too. The fluconazole label: “Cyclosporine Fluconazole significantly increases cyclosporine levels in renal transplant patients with or without renal impairment.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the cyclosporine label say about fluconazole?
Cyclosporine label, drug interactionsdiltiazem; fluconazole; azithromycin; methylprednisolone; Allopurinol
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the fluconazole label say about cyclosporine?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsCyclosporine Fluconazole significantly increases cyclosporine levels in renal transplant patients with or without renal impairment.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Fluconazole | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Fungal infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once