What the FDA labels say about taking them together
Filgrastim and pegfilgrastim
Filgrastim's FDA label of July 23, 2026 names pegfilgrastim in its contraindications section, and pegfilgrastim's label names filgrastim too. The pegfilgrastim label: “Neulasta is contraindicated in patients with a history of a serious hypersensitivity reaction to pegfilgrastim or filgrastim.”
Check it at the source: the filgrastim FDA label on DailyMed (effective July 23, 2026, Amgen, Inc); the pegfilgrastim FDA label on DailyMed (effective August 10, 2026, Amgen, Inc).
What does the filgrastim label say about pegfilgrastim?
Filgrastim label, contraindicationsCONTRAINDICATIONS NEUPOGEN is contraindicated in patients with a history of serious allergic reactions to human granulocyte colony-stimulating factors such as filgrastim or pegfilgrastim [see Warnings and Precautions (5.3) ].
Source: FDA drug label (Nivestym, BLA761080), Pfizer Laboratories Div Pfizer Inc, effective August 12, 2025 (SPL set d23ab39c-b6ec-41cf-a529-9dd2852c9d9a), via openFDA
Source: FDA drug label (NEUPOGEN), Amgen, Inc, effective July 23, 2026 (SPL set 97cc73cc-b5b7-458a-a933-77b00523e193), via openFDA; the full label on DailyMed
What does the pegfilgrastim label say about filgrastim?
Pegfilgrastim label, contraindicationsCONTRAINDICATIONS Neulasta is contraindicated in patients with a history of a serious hypersensitivity reaction to pegfilgrastim or filgrastim.
Udenyca label (Accord BioPharma, Inc., April 23, 2026), contraindicationsCONTRAINDICATIONS UDENYCA is contraindicated in patients with a history of serious allergic reactions to pegfilgrastim products or filgrastim products.
Source: FDA drug label (Udenyca, BLA761039), Accord BioPharma, Inc., effective April 23, 2026 (SPL set 77a8576f-b91e-42ce-b613-2fa3c3d4a571), via openFDA
Source: FDA drug label (Neulasta), Amgen, Inc, effective August 10, 2026 (SPL set fdfe5d72-6b80-435a-afa4-c5d74dd852ce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Filgrastim | Pegfilgrastim | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $650.05 per mL 300 mcg/0.5 mL syringe | $3,369.51 per mL 6 mg/0.6 mL syringe |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once