What the FDA labels say about taking them together
Ferric oxyhydroxide and hydrochlorothiazide
Ferric oxyhydroxide's FDA label of April 1, 2026 names hydrochlorothiazide in its drug interactions section; the hydrochlorothiazide labels PlainMeds reads (3) do not name ferric oxyhydroxide.
Check it at the source: the ferric oxyhydroxide FDA label on DailyMed (effective April 1, 2026, Fresenius Medical Care Renal Therapies Group, LLC); the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC).
What does the ferric oxyhydroxide label say about hydrochlorothiazide?
Ferric oxyhydroxide label, drug interactionsDRUG INTERACTIONS Table 1 Oral drugs that can be administered concomitantly with Velphoro Calcitriol Ciprofloxacin Digoxin Enalapril Furosemide HMG-CoA reductase inhibitors Hydrochlorothiazide Losartan Metoprolol Nifedipine Omeprazole Quinidine Warfarin Oral drugs that are to be separated from Velphoro Dosing Recommendations Doxycycline Acetylsalicylic acid Cephalexin Take at least 1 hour before Velphoro.
Source: FDA drug label (Velphoro), Fresenius Medical Care Renal Therapies Group, LLC, effective April 1, 2026 (SPL set 237da26c-f38c-4faa-93ad-735e71c9d0c1), via openFDA; the full label on DailyMed
What does the hydrochlorothiazide label say about ferric oxyhydroxide?
Hydrochlorothiazide's label (effective June 12, 2026) and its 2 other brand-application labels do not name ferric oxyhydroxide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ferric oxyhydroxide | Hydrochlorothiazide | |
|---|---|---|
| Labeled for | n/a | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $17.11 per tablet 500 mg chewable tablet | $0.0115 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once