What the FDA labels say about taking them together
Fentanyl and nifedipine
Nifedipine's FDA label of December 24, 2024 names fentanyl in its warnings section; the fentanyl labels PlainMeds reads (2) do not name nifedipine. The nifedipine label: “… beta-blocking agent and who underwent coronary artery bypass surgery using high dose fentanyl anesthesia.”
Check it at the source: the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the fentanyl label say about nifedipine?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name nifedipine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
What does the nifedipine label say about fentanyl?
Nifedipine label, warningsSevere hypotension and/or increased fluid volume requirements have been reported in patients who received immediate release capsules together with a beta-blocking agent and who underwent coronary artery bypass surgery using high dose fentanyl anesthesia.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fentanyl | Nifedipine | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Angina |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.79 per mL 100 mcg/2 mL vial | $0.130 per tablet 30 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once