What the FDA labels say about taking them together
Fentanyl and methamphetamine
Methamphetamine's FDA label of September 30, 2024 names fentanyl in its warnings and precautions section; the fentanyl labels PlainMeds reads (2) do not name methamphetamine. The methamphetamine label: “… norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort.”
Check it at the source: the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.); the methamphetamine FDA label on DailyMed (effective September 30, 2024, Hikma Pharmaceuticals USA Inc.).
What does the fentanyl label say about methamphetamine?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name methamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
What does the methamphetamine label say about fentanyl?
Methamphetamine label, warnings and precautionsSerotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Methamphetamine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective September 30, 2024 (SPL set 90c02ac6-e5e2-4c97-8c68-81e4e389a195), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fentanyl | Methamphetamine | |
|---|---|---|
| Labeled for | Pain | ADHD |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.79 per mL 100 mcg/2 mL vial | $5.10 per tablet 5 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once