What the FDA labels say about taking them together
Fentanyl and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name fosamprenavir. The fosamprenavir label: “Careful monitoring of therapeutic effects and adverse effects of fentanyl is recommended.”
Check it at the source: the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the fentanyl label say about fosamprenavir?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about fentanyl?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Fentanyl; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Fentanyl; Clinical Comment: Careful monitoring of therapeutic effects and adverse effects of fentanyl (including potentially fatal respiratory depression) is recommended.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fentanyl | Fosamprenavir | |
|---|---|---|
| Labeled for | Pain | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.79 per mL 100 mcg/2 mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once