What the FDA labels say about taking them together
Fenoprofen and methotrexate
Fenoprofen's FDA label of August 20, 2026 names methotrexate in its drug interactions section; methotrexate's label does not name fenoprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The fenoprofen label: “Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity.”
Check it at the source: the fenoprofen FDA label on DailyMed (effective August 20, 2026, Misemer Pharmaceuticals, Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the fenoprofen label say about methotrexate?
Fenoprofen label, drug interactionsMethotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (…). Intervention: During concomitant use of FENOPROFEN CALCIUM and methotrexate, monitor patients for methotrexate toxicity.
Source: FDA drug label (Fenoprofen Calcium), Misemer Pharmaceuticals, Inc., effective August 20, 2026 (SPL set d33ad329-1ca6-ac2e-e053-2995a90a15c5), via openFDA; the full label on DailyMed
What does the methotrexate label say about fenoprofen?
Methotrexate's label does not name fenoprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Methotrexate label, boxed warningUnexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity have been reported with concomitant administration of methotrexate (usually in high dosage) along with some nonsteroidal anti-inflammatory drugs (NSAIDs) [see Warnings and Precautions (5.1) and Drug Interactions(7.1) ].
Methotrexate label, drug interactionsConcomitant administration of some NSAIDs with high dose methotrexate therapy has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and gastrointestinal toxicity [see Warnings and Precautions (5.1) ].
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fenoprofen | Methotrexate | |
|---|---|---|
| Labeled for | Pain, Rheumatoid arthritis, Osteoarthritis | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once