What the FDA labels say about taking them together
Fenofibric acid and tacrolimus
Fenofibric acid's FDA label of August 2, 2025 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name fenofibric acid. The fenofibric acid label: “Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of …”
Check it at the source: the fenofibric acid FDA label on DailyMed (effective August 2, 2025, Aurobindo Pharma Limited); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the fenofibric acid label say about tacrolimus?
Fenofibric acid label, drug interactionsImmunosuppressants Clinical Impact: Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including fenofibric acid delayed-release capsules, there is a risk that an interaction will lead to … Intervention: The benefits and risks of using fenofibric acid delayed-release capsules with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dosage employed and renal function monitored.
Source: FDA drug label (FENOFIBRIC ACID), Aurobindo Pharma Limited, effective August 2, 2025 (SPL set 9ad201de-fa62-4c49-bc61-ee09b9ba434c), via openFDA; the full label on DailyMed
What does the tacrolimus label say about fenofibric acid?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name fenofibric acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fenofibric acid | Tacrolimus | |
|---|---|---|
| Labeled for | High cholesterol, High triglycerides | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.286 per capsule 135 mg capsule | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once