What the FDA labels say about taking them together

Fenfluramine and stiripentol

Fenfluramine's FDA label of October 27, 2025 names stiripentol in its drug interactions section; the stiripentol label PlainMeds reads does not name fenfluramine. The fenfluramine label: “DRUG INTERACTIONS Dose adjustment is required for patients taking stiripentol plus clobazam. Strong CYP1A2 or CYP2D6 inhibitors: a dose adjustment is recommended Strong CYP1A2, CYP2B6, or CYP3A4 inducers: it is …”

Check it at the source: the fenfluramine FDA label on DailyMed (effective October 27, 2025, UCB, Inc.); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).

What does the fenfluramine label say about stiripentol?

Fenfluramine label, drug interactions
DRUG INTERACTIONS Dose adjustment is required for patients taking stiripentol plus clobazam. ( 2.2 , 2.3 , 7.1 ) Strong CYP1A2 or CYP2D6 inhibitors: a dose adjustment is recommended ( 2.3 , 7.1 ) Strong CYP1A2, CYP2B6, or CYP3A4 inducers: it is recommended to avoid coadministration with FINTEPLA.

Fenfluramine label, warnings and precautions
In the controlled studies for DS, 26% of patients on FINTEPLA 0.7 mg/kg/day (Study 1), 19% of patients on FINTEPLA 0.4 mg/kg/day in combination with stiripentol (Study 2), and 13% of patients taking FINTEPLA 0.2 mg/kg/day (Study 1) experienced at least a 7% decrease in weight from baseline.

Source: FDA drug label (Fintepla), NDA212102 (Ucb Inc), as published by UCB, Inc., effective October 27, 2025 (SPL set e88f360e-33ad-4cd6-b2de-5ef885857c5d), via openFDA; the full label on DailyMed

What does the stiripentol label say about fenfluramine?

Stiripentol's label (effective April 27, 2026) does not name fenfluramine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Fenfluramine generic labelers

0Stiripentol generic labelers

	Fenfluramine	Stiripentol
Labeled for	n/a	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	n/a	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Fenfluramine: the full record
Stiripentol: the full record
Check more medicines together: up to five at once