What the FDA labels say about taking them together
Fedratinib and metformin
Fedratinib's FDA label of July 20, 2026 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name fedratinib. The fedratinib label: “Monitor for adverse reactions and consider dose modifications for drugs that are renally excreted via OCT2 or MATE1/2-K (e.g., metformin), as necessary when coadministered with INREBIC.”
Check it at the source: the fedratinib FDA label on DailyMed (effective July 20, 2026, Celgene Corporation); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the fedratinib label say about metformin?
Fedratinib label, drug interactionsMonitor for adverse reactions and consider dose modifications for drugs that are renally excreted via OCT2 or MATE1/2-K (e.g., metformin), as necessary when coadministered with INREBIC.
Source: FDA drug label (Inrebic), NDA212327 (Bristol-Myers), as published by Celgene Corporation, effective July 20, 2026 (SPL set f0f55a2a-4e0c-4cba-8571-03e1424486d7), via openFDA; the full label on DailyMed
What does the metformin label say about fedratinib?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name fedratinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fedratinib | Metformin | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once