What the FDA labels say about taking them together
Famotidine/ibuprofen and ketoconazole
Famotidine/ibuprofen's FDA label of July 3, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name famotidine/ibuprofen. The famotidine/ibuprofen label: “Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs.”
Check it at the source: the famotidine/ibuprofen FDA label on DailyMed (effective July 3, 2025, Aurobindo Pharma Limited); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the famotidine/ibuprofen label say about ketoconazole?
Famotidine/ibuprofen label, drug interactionsDrugs Dependent on Gastric pH for Absorption Clinical Impact: Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs. … absorption is dependent on gastric pH, refer to their prescribing information (e.g., atazanavir, erlotinib, ketoconazole, itraconazole, nilotinib, ledipasvir/sofosbuvir, and rilpivirine).
Source: FDA drug label (Ibuprofen and famotidine), Aurobindo Pharma Limited, effective July 3, 2025 (SPL set 21688404-41fb-487e-8ba0-aea4431a42fa), via openFDA; the full label on DailyMed
What does the ketoconazole label say about famotidine/ibuprofen?
Ketoconazole's label (effective January 28, 2026) does not name famotidine/ibuprofen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Famotidine/ibuprofen | Ketoconazole | |
|---|---|---|
| Labeled for | Osteoarthritis, Rheumatoid arthritis | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.714 per unit 800-26.6 mg | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once