What the FDA labels say about taking them together
Famotidine/ibuprofen and itraconazole
Famotidine/ibuprofen's FDA label of July 3, 2025 names itraconazole in its drug interactions section; itraconazole's label does not name famotidine/ibuprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The famotidine/ibuprofen label: “Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs.”
Check it at the source: the famotidine/ibuprofen FDA label on DailyMed (effective July 3, 2025, Aurobindo Pharma Limited); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the famotidine/ibuprofen label say about itraconazole?
Famotidine/ibuprofen label, drug interactionsDrugs Dependent on Gastric pH for Absorption Clinical Impact: Because famotidine lowers intra-gastric acidity, this may result in reduced absorption and loss of efficacy of concomitant drugs. … dependent on gastric pH, refer to their prescribing information (e.g., atazanavir, erlotinib, ketoconazole, itraconazole, nilotinib, ledipasvir/sofosbuvir, and rilpivirine).
Source: FDA drug label (Ibuprofen and famotidine), Aurobindo Pharma Limited, effective July 3, 2025 (SPL set 21688404-41fb-487e-8ba0-aea4431a42fa), via openFDA; the full label on DailyMed
What does the itraconazole label say about famotidine/ibuprofen?
Itraconazole's label does not name famotidine/ibuprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Itraconazole label, drug interactionsNonsteroidal Anti-Inflammatory Drugs Meloxicam Concomitant drug dose increase may be necessary.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Famotidine/ibuprofen | Itraconazole | |
|---|---|---|
| Labeled for | Osteoarthritis, Rheumatoid arthritis | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.714 per unit 800-26.6 mg | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once