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What the FDA labels say about taking them together

Famotidine and thalidomide

Thalidomide's FDA label of March 24, 2023 names famotidine in its drug interactions section; the famotidine labels PlainMeds reads (2) do not name thalidomide.

Check it at the source: the famotidine FDA label on DailyMed (effective February 6, 2026, Kenvue Brands LLC); the thalidomide FDA label on DailyMed (effective March 24, 2023, Celgene Corporation).

What does the famotidine label say about thalidomide?

Famotidine's label (effective February 6, 2026) and its 1 other brand-application label do not name thalidomide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Pepcid AC Original Strength), Kenvue Brands LLC, effective February 6, 2026 (SPL set 54f4086f-e443-4e7e-8c7e-94e152e1c256), via openFDA; the full label on DailyMed

What does the thalidomide label say about famotidine?

Thalidomide label, drug interactions

Non-cardiac drugs that may cause bradycardia include H2 blockers (e.g., famotidine, cimetidine), lithium, tricyclic antidepressants and neuromuscular blockers (succinylcholine).

Source: FDA drug label (Thalomid), NDA020785 (Bristol-Myers), as published by Celgene Corporation, effective March 24, 2023 (SPL set 2eda833b-1357-4ed4-a093-194524fcb061), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

145Famotidine generic labelers
0Thalidomide generic labelers
FamotidineThalidomide
Labeled forAcid reflux and ulcersLeukemia, lymphoma and myeloma
Boxed warningNoYes
Pharmacy cost (NADAC)$0.0289 per tablet 20 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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