What the FDA labels say about taking them together
Famotidine and rilpivirine
Famotidine's FDA label of February 6, 2026 names rilpivirine in its drug interactions (prescription label) section, and rilpivirine's label names famotidine too. The rilpivirine label: “The combination of EDURANT or EDURANT PED and H 2 -receptor antagonists should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). …”
Check it at the source: the famotidine FDA label on DailyMed (effective February 6, 2026, Kenvue Brands LLC); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the famotidine label say about rilpivirine?
Famotidine label, drug interactions (prescription label)See the prescribing information for other drugs dependent on gastric pH for absorption for administration instructions, including atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, and rilpivirine.
Source: FDA drug label (Pepcid AC Original Strength), Kenvue Brands LLC, effective February 6, 2026 (SPL set 54f4086f-e443-4e7e-8c7e-94e152e1c256), via openFDA; the full label on DailyMed
What does the rilpivirine label say about famotidine?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: H 2 -Receptor Antagonists: cimetidine famotidine nizatidine ranitidine; Effect on Concentration of Rilpivirine or Concomitant Drug: ↔ rilpivirine (famotidine taken 12 hours before rilpivirine or 4 hours after rilpivirine); Clinical Comment: The combination of EDURANT or EDURANT PED and H 2 -receptor antagonists should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). H 2 -receptor antagonists should only be administered at least 12 hours before or at least 4 hours after EDURANT or EDURANT PED.
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Famotidine | Rilpivirine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0289 per tablet 20 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once