What the FDA labels say about taking them together
Cholestyramine and ezetimibe
Ezetimibe's FDA label of November 25, 2025 names cholestyramine in its drug interactions section; the cholestyramine label PlainMeds reads does not name ezetimibe. The ezetimibe label: “Concomitant cholestyramine administration decreased the mean exposure of total ezetimibe. This may result in a reduction of efficacy.”
Check it at the source: the cholestyramine FDA label on DailyMed (effective August 20, 2026, AiPing Pharmaceutical, Inc.); the ezetimibe FDA label on DailyMed (effective November 25, 2025, Organon LLC).
What does the cholestyramine label say about ezetimibe?
Cholestyramine's label (effective August 20, 2026) does not name ezetimibe in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cholestyramine), AiPing Pharmaceutical, Inc., effective August 20, 2026 (SPL set 214ea05f-de81-4026-9df9-4ce3820668ee), via openFDA; the full label on DailyMed
What does the ezetimibe label say about cholestyramine?
Ezetimibe label, drug interactionsClinical Impact: Concomitant cholestyramine administration decreased the mean exposure of total ezetimibe. This may result in a reduction of efficacy. … are indicated, and alternative lipid-lowering therapy should be considered. ( 7 ) Bile Acid Sequestrants: Cholestyramine combination decreases exposure of ZETIA.
Source: FDA drug label (Zetia), Organon LLC, effective November 25, 2025 (SPL set 174e45e0-45bb-48b7-9e60-8f6cfc1d22bb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cholestyramine | Ezetimibe | |
|---|---|---|
| Labeled for | High cholesterol | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.834 per packet Cholestyramine packet | $0.0667 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once