What the FDA labels say about taking them together
Everolimus and sirolimus
Everolimus's FDA label (Zortress) of February 12, 2026 names sirolimus in its contraindications section; the sirolimus labels PlainMeds reads (4) do not name everolimus.
Check it at the source: the everolimus FDA label on DailyMed (effective June 1, 2026, Novartis Pharmaceuticals Corporation); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the everolimus label say about sirolimus?
Zortress label (Novartis Pharmaceuticals Corporation, February 12, 2026), contraindicationsCONTRAINDICATIONS Hypersensitivity to everolimus, sirolimus, or to components of the drug product
Source: FDA drug label (Zortress, NDA021560), Novartis Pharmaceuticals Corporation, effective February 12, 2026 (SPL set e082a024-7850-400b-a5c2-2a140612562a), via openFDA
Source: FDA drug label (Afinitor), Novartis Pharmaceuticals Corporation, effective June 1, 2026 (SPL set 2150f73a-179b-4afc-b8ce-67c85cc72f04), via openFDA; the full label on DailyMed
What does the sirolimus label say about everolimus?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name everolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Everolimus | Sirolimus | |
|---|---|---|
| Labeled for | Breast cancer, Seizures and epilepsy, Organ transplant rejection | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $26.32 per tablet 10 mg tablet | $0.723 per tablet 1 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once