What the FDA labels say about taking them together
Everolimus and ivacaftor/tezacaftor
Ivacaftor/tezacaftor's FDA label of August 21, 2026 names everolimus in its drug interactions section; the everolimus labels PlainMeds reads (2) do not name ivacaftor/tezacaftor. The ivacaftor/tezacaftor label: “When used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus, and tacrolimus, caution and appropriate monitoring should be used.”
Check it at the source: the everolimus FDA label on DailyMed (effective June 1, 2026, Novartis Pharmaceuticals Corporation); the ivacaftor/tezacaftor FDA label on DailyMed (effective August 21, 2026).
What does the everolimus label say about ivacaftor/tezacaftor?
Everolimus's label (effective June 1, 2026) and its 1 other brand-application label do not name ivacaftor/tezacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Afinitor), Novartis Pharmaceuticals Corporation, effective June 1, 2026 (SPL set 2150f73a-179b-4afc-b8ce-67c85cc72f04), via openFDA; the full label on DailyMed
What does the ivacaftor/tezacaftor label say about everolimus?
Ivacaftor/tezacaftor label, drug interactionsWhen used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus, and tacrolimus, caution and appropriate monitoring should be used [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (SYMDEKO), Vertex Pharmaceuticals Incorporated, effective August 21, 2026 (SPL set 302ae804-37db-44fd-ac2f-3dbdeda9aa4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Everolimus | Ivacaftor/tezacaftor | |
|---|---|---|
| Labeled for | Breast cancer, Seizures and epilepsy, Organ transplant rejection | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $26.32 per tablet 10 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once