What the FDA labels say about taking them together
Etravirine and sirolimus
Etravirine's FDA label of August 15, 2023 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name etravirine. The etravirine label: “INTELENCE and systemic immunosuppressants should be co-administered with caution because plasma concentrations of cyclosporine, sirolimus, or tacrolimus may be affected.”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the etravirine label say about sirolimus?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: Immunosuppressants: cyclosporine sirolimus tacrolimus; Effect on Concentration of Etravirine or Concomitant Drug: ↓ immunosuppressant; Clinical Comment: INTELENCE and systemic immunosuppressants should be co-administered with caution because plasma concentrations of cyclosporine, sirolimus, or tacrolimus may be affected.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the sirolimus label say about etravirine?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Sirolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.723 per tablet 1 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once