What the FDA labels say about taking them together
Etravirine and simvastatin
Etravirine's FDA label of August 15, 2023 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name etravirine. The etravirine label: “Lovastatin and simvastatin are CYP3A substrates and co-administration with INTELENCE may result in lower plasma concentrations of the HMG-CoA reductase inhibitor.”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the etravirine label say about simvastatin?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: lovastatin simvastatin; Effect on Concentration of Etravirine or Concomitant Drug: ↓ lovastatin ↓ simvastatin; Clinical Comment: Lovastatin and simvastatin are CYP3A substrates and co-administration with INTELENCE may result in lower plasma concentrations of the HMG-CoA reductase inhibitor.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the simvastatin label say about etravirine?
Simvastatin's label (effective March 28, 2025) does not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Simvastatin | |
|---|---|---|
| Labeled for | HIV | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once