What the FDA labels say about taking them together
Etravirine and rilpivirine
Etravirine's FDA label of August 15, 2023 names rilpivirine in its drug interactions section, and rilpivirine's label names etravirine too. The etravirine label: “Combining two NNRTIs has not been shown to be beneficial. Co-administration of INTELENCE and rilpivirine is not recommended.”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the etravirine label say about rilpivirine?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: rilpivirine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ rilpivirine ↔ etravirine; Clinical Comment: Combining two NNRTIs has not been shown to be beneficial. Co-administration of INTELENCE and rilpivirine is not recommended.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the rilpivirine label say about etravirine?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Other NNRTIs (efavirenz, etravirine, nevirapine); Effect on Concentration of Rilpivirine or Concomitant Drug: ↓ rilpivirine ↔ other NNRTIs
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Rilpivirine | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $48.04 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once