What the FDA labels say about taking them together
Etravirine and rifampin
Etravirine's FDA label of August 15, 2023 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name etravirine. The etravirine label: “Rifampin and rifapentine are potent inducers of CYP450 enzymes. INTELENCE should not be used with rifampin or rifapentine as co-administration may cause significant decreases in etravirine plasma concentrations and loss …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the etravirine label say about rifampin?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: Antimycobacterials: rifampin rifapentine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ etravirine; Clinical Comment: Rifampin and rifapentine are potent inducers of CYP450 enzymes. INTELENCE should not be used with rifampin or rifapentine as co-administration may cause significant decreases in etravirine plasma concentrations and loss of therapeutic effect of INTELENCE.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the rifampin label say about etravirine?
Rifampin's label (effective February 11, 2026) does not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Rifampin | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once