What the FDA labels say about taking them together
Etravirine and propafenone
Etravirine's FDA label of August 15, 2023 names propafenone in its drug interactions section; the propafenone label PlainMeds reads does not name etravirine. The etravirine label: “Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the etravirine label say about propafenone?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: amiodarone bepridil disopyramide flecainide lidocaine (systemic) mexiletine propafenone quinidine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ antiarrhythmics; Clinical Comment: Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. Drug concentration monitoring is recommended, if available.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the propafenone label say about etravirine?
Propafenone's label (effective September 1, 2025) does not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Propafenone | |
|---|---|---|
| Labeled for | HIV | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once