What the FDA labels say about taking them together
Etravirine and posaconazole
Etravirine's FDA label of August 15, 2023 names posaconazole in its drug interactions section; the posaconazole labels PlainMeds reads (2) do not name etravirine. The etravirine label: “Posaconazole, a potent inhibitor of CYP3A4, may increase plasma concentrations of etravirine. Itraconazole and ketoconazole are potent inhibitors as well as substrates of CYP3A4. …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the etravirine label say about posaconazole?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: itraconazole ketoconazole posaconazole; Effect on Concentration of Etravirine or Concomitant Drug: ↑ etravirine ↓ itraconazole ↓ ketoconazole ↔ posaconazole; Clinical Comment: Posaconazole, a potent inhibitor of CYP3A4, may increase plasma concentrations of etravirine. Itraconazole and ketoconazole are potent inhibitors as well as substrates of CYP3A4. Concomitant systemic use of itraconazole or ketoconazole and INTELENCE may increase plasma concentrations of etravirine. Simultaneously, plasma concentrations of itraconazole or ketoconazole may be decreased by INTELENCE. …
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the posaconazole label say about etravirine?
Posaconazole's label (effective August 3, 2026) and its 1 other brand-application label do not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Posaconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $2.03 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once