What the FDA labels say about taking them together
Etravirine and nevirapine
Etravirine's FDA label of August 15, 2023 names nevirapine in its drug interactions section, and nevirapine's label names etravirine too. The etravirine label: “Combining two NNRTIs has not been shown to be beneficial. Concomitant use of INTELENCE with efavirenz or nevirapine may cause a significant decrease in the plasma concentrations of etravirine and loss of therapeutic …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the nevirapine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the etravirine label say about nevirapine?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: efavirenz nevirapine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ etravirine; Clinical Comment: Combining two NNRTIs has not been shown to be beneficial. Concomitant use of INTELENCE with efavirenz or nevirapine may cause a significant decrease in the plasma concentrations of etravirine and loss of therapeutic effect of INTELENCE. Co-administration of INTELENCE and other NNRTIs is not recommended.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the nevirapine label say about etravirine?
Nevirapine label, drug interactionsEtravirine Rilpivirine Plasma concentrations may be altered.
Source: FDA drug label (Nevirapine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set c6e93829-7024-48f6-8023-da6ff27dfc0a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Nevirapine | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.147 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once