What the FDA labels say about taking them together
Etravirine and lidocaine
Etravirine's FDA label of August 15, 2023 names lidocaine in its drug interactions section; the lidocaine labels PlainMeds reads (4) do not name etravirine. The etravirine label: “Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. …”
Check it at the source: the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP); the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC).
What does the etravirine label say about lidocaine?
Etravirine label, drug interactionsConcomitant Drug Class/Drug Name: amiodarone bepridil disopyramide flecainide lidocaine (systemic) mexiletine propafenone quinidine; Effect on Concentration of Etravirine or Concomitant Drug: ↓ antiarrhythmics; Clinical Comment: Concentrations of these antiarrhythmics may be decreased when co-administered with INTELENCE. INTELENCE and antiarrhythmics should be co-administered with caution. Drug concentration monitoring is recommended, if available.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
What does the lidocaine label say about etravirine?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name etravirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etravirine | Lidocaine | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.94 per tablet 200 mg tablet | $0.154 per gram 5% ointment |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once