What the FDA labels say about taking them together
Etrasimod arginine and sotalol
Etrasimod arginine's FDA label of August 18, 2025 names sotalol in its drug interactions section; the sotalol labels PlainMeds reads (3) do not name etrasimod arginine. The etrasimod arginine label: “Prevention or Management; Seek the advice of a cardiologist before initiating VELSIPITY treatment with Class Ia, Class III anti-arrhythmic drugs, or other drugs that prolong the QT interval.”
Check it at the source: the etrasimod arginine FDA label on DailyMed (effective August 18, 2025, Pfizer Laboratories Div Pfizer Inc); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the etrasimod arginine label say about sotalol?
Etrasimod arginine label, drug interactionsPrevention or Management; Seek the advice of a cardiologist before initiating VELSIPITY treatment with Class Ia (e.g., quinidine, procainamide), Class III anti-arrhythmic drugs (e.g., amiodarone, sotalol), or other drugs that prolong the QT interval.
Source: FDA drug label (Velsipity), Pfizer Laboratories Div Pfizer Inc, effective August 18, 2025 (SPL set 65171e4a-d136-4abc-b08c-c40c1b486ff6), via openFDA; the full label on DailyMed
What does the sotalol label say about etrasimod arginine?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name etrasimod arginine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etrasimod arginine | Sotalol | |
|---|---|---|
| Labeled for | Crohn's disease and ulcerative colitis | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once