What the FDA labels say about taking them together
Etrasimod arginine and fluconazole
Etrasimod arginine's FDA label of August 18, 2025 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name etrasimod arginine. The etrasimod arginine label: “Clinical Impact; Increased exposure of etrasimod was observed with concomitant use with a drug that is a moderate inhibitor of CYP2C9 and a moderate inhibitor of CYP3A4 (i.e., fluconazole).”
Check it at the source: the etrasimod arginine FDA label on DailyMed (effective August 18, 2025, Pfizer Laboratories Div Pfizer Inc); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the etrasimod arginine label say about fluconazole?
Etrasimod arginine label, drug interactionsClinical Impact; Increased exposure of etrasimod was observed with concomitant use with a drug that is a moderate inhibitor of CYP2C9 and a moderate inhibitor of CYP3A4 (i.e., fluconazole) [see ].
Source: FDA drug label (Velsipity), Pfizer Laboratories Div Pfizer Inc, effective August 18, 2025 (SPL set 65171e4a-d136-4abc-b08c-c40c1b486ff6), via openFDA; the full label on DailyMed
What does the fluconazole label say about etrasimod arginine?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name etrasimod arginine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Etrasimod arginine | Fluconazole | |
|---|---|---|
| Labeled for | Crohn's disease and ulcerative colitis | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once